The main secretion parts of BNP are in ventricular. People in the synthesis of myocardial cells first is to contain 108 amino acids of type B natriuretic peptides original (proBNP), after cutting, under the action of the enzyme were cut for containing 76 amino acids N end type B natriuretic peptide original (NT-proBNP, MW 8.5 kD) and contain 32 of the C amino acid peptide BNP (MW 3.5 kD).
Natriuretic peptide main physiological function is diuresis platoon sodium, inhibit renin-the renin-angiotensin-aldosterone system, (RAAS) the dilation of blood vessels and inhibit vascular smooth muscle cell proliferation, etc.
NT proBNP don't have biological activities. When ventricular capacity load or pressure load increases, the myocardial synthesis and release the BNP/NT-proBNP will increase.
Foreign large multi-center clinical trials of the results confirm, BNP/NT-proBNP heart failure diagnosis is fairly good myocardial markers.
The half-life of BNP for 22 min, NT-proBNP half-life for 120 min, so, NT-proBNP in heart failure patients in the blood level than BNP high 1 times ~ 10 times, is more advantageous to the diagnosis of HF and laboratory determined.
BNP is extremely negative predictive value (96%), according to BNP may exclude 96% of the patients with heart failure .
没有评论:
发表评论