2012年5月28日星期一

In vitro diagnostic reagent suppresses HIV persistent method in medical released online

   Why the AIDS virus HIV so difficult to treatment? One reason is that a large part of HIV-1 virus that durability. Through the in vitro diagnostic reagents research found that the persistence can make the virus on the treatment scheme does not produce any response.


    Recently, scientists through in vitro diagnostic reagent found a way to eliminate effectively HIV-1 the persistent virus, thus, treat HIV-1 virus infection process and move forward the important one step further. The in vitro diagnostic reagent in network by Cell Press published in medical equipment online, it expounds said, injection prevention vaccine is successful the extinction of the HIV virus-1 the key, and can be used for further clinical trials. The current antiretroviral therapy suppresses HIV is the purpose of the virus-1 copy themselves, but this kind of treatment and can't completely eliminate the virus. In the therapeutic scheme, the in vitro diagnostic reagents test found that HIV-1 virus enters a resting phase, or is called "incubation period", in which the incubation period, once the treatment is terminated, the virus immediately and get active. 


    "Because infected T cells HIV-1 virus in the incubation period has certain stability, this needs to patients for a lifetime of antiretroviral therapy in decades, and the treatment of the people, and increase of the side effects of the treatment of concern, also make the virus's resistance to evolve, and such treatment will give patients but to the huge economic burden." The study of the corresponding author, John Hopkins university school of medicine, Robert f. Siliciano doctor complain say, "so, need a treatment plan to eliminate completely infected individuals of the HIV virus in the body-1. The former in vitro diagnostic reagent points out, eliminate completely HIV an important first step is to HIV-1 virus in the incubation period will be reactivated, but did not specify a research those activated the virus or the host immune response would further destroy infected cells. 


    In a recent study, dr Siliciano and his team observed the incubation period of the virus is enabled, infected T cells still survive, however, if the virus was before the activation of infected T cells enhance the immune response ability, infected cells can be effectively eliminate." we of in vitro diagnostic reagent show that activate incubation period of HIV-1 May not clear the incubation period of the virus and reserves, in the virus is activated stimulate T cells before the HIV-1 specific immune response is completely remove the main points of the virus. "Siliciano concluded," so, at the right time can promote cell vaccine for HIV-1 the immune response, this may be for the treatment by suppresses HIV-1 virus development into real remove viruses is very important.

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